Invitrogen™ Desmoglein 3 Monoclonal Antibody (5G11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 326300

Catalog No. 32-630-0

Description

Desmoglein 3 Monoclonal Antibody for Western Blot, IHC, IP

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.

Specifications

• Antigen: Desmoglein 3
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: P32926
• Gene Symbols: Dsg3
• Immunogen: Human desmoglein-3 extracellular domain.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Clone: 5G11
• Conjugate: Unconjugated
• Gene: Dsg3
• Gene Alias: 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; bal; balding; Cadherin family member 6; CDHF6; desmoglein 3; desmoglein-3; DKFZp686P23184; Dsg3; PVA
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1830
• Content And Storage: -20°C
• Form: Liquid