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Invitrogen™ Desmoglein 3 Polyclonal Antibody
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Catalog No. PIPA5114323 Shop All Thermo Scientific Products
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PIPA5114323 100 μL
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Catalog No. PIPA5114323 Supplier Invitrogen™ Supplier No. PA5114323
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Description

Rabbit Polyclonal Antibody

Desmoglein 3 Polyclonal Antibody for Flow, ICC/IF, IHC (P), Western Blot

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Desmoglein 3
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Dsg3
Gene Accession No. O35902, P32926
Gene Alias 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; bal; balding; Cadherin family member 6; CDHF6; desmoglein 3; desmoglein-3; DKFZp686P23184; Dsg3; PVA
Gene Symbols Dsg3
Host Species Rabbit
Immunogen Recombinant protein within Human DSG3 aa 709-897.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13512, 1830, 291752
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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