Di-tert-butyl N,N-diethylphosphoramidite, 94%

Description

CAS: 117924-33-1 | C12H28NO2P | 249.335 g/mol

A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.

Solubility
Hydrolyzes in water. Soluble in chloroform and methanol.

Notes
Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.

Specifications

Chemical Identifiers

• CAS: 117924-33-1
• Molecular Formula: C12H28NO2P
• Molecular Weight (g/mol): 249.335
• MDL Number: MFCD00134307
• InChI Key: KUKSUQKELVOKBH-UHFFFAOYSA-N
• Synonym: di-tert-butyl n,n-diethylphosphoramidite, di-tert-butyl diethylphosphoramidite, di-t-butyl n,n-diethylphosphoramidite, phosphoramidous acid, diethyl-, bis 1,1-dimethylethyl ester, n-bis 2-methylpropan-2-yl oxy phosphanyl-n-ethylethanamine, acmc-1c42i, di-t-butyl diethylphosphoramidite, di-tert-butyl diethylamidophosphite, di-tert-butoxy diethylamino phosphine
• PubChem CID: 4251849
• IUPAC Name: N-[bis[(2-methylpropan-2-yl)oxy]phosphanyl]-N-ethylethanamine
• SMILES: CCN(CC)P(OC(C)(C)C)OC(C)(C)C

• Density: 0.896
• Boiling Point: 39°C to 41°C (0.3 mmHg)
• Flash Point: 78°C (172°F)
• Refractive Index: 1.434
• Quantity: 5 g
• Sensitivity: Moisture sensitive; May form a precipitate
• Solubility Information: Hydrolyzes in water. Soluble in chloroform and methanol.
• Formula Weight: 249.33
• Percent Purity: 94%
• Chemical Name or Material: Di-tert-butyl N,N-diethylphosphoramidite

Safety and Handling

Hazard Category	H227-H315-H319
Hazard Statement	GHS H Statement H315-H319-H227 Causes skin irritation. Causes serious eye irritation. Combustible liquid.
Precautionary Statement	P210-P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362-P370+P378q-P501c
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only