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DICER1 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501732966 Shop All Proteintech Group Inc Products
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50-173-2966 150 μL
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Catalog No. 50-173-2966 Supplier Proteintech Group Inc Supplier No. 205671AP150UL
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Description

Rabbit Polyclonal Antibody

The antibody is specific to DICER1. The calculated molecular weight of DICER1 is 219 kDa, but modified DICER1 is about 220-250 kDa. DICER1 has isoforms with molecular weight 219 kDa and 93 kDa.

Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.

Specifications

Antigen DICER1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.57 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene DICER1
Gene Accession No. Q9UPY3
Gene Alias DCR1, Dicer, dicer 1, ribonuclease type III, DICER1, Endoribonuclease Dicer, Helicase MOI, Helicase with RNase motif, HERNA, KIAA0928
Gene Symbols DICER1
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23405
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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