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Cayman Chemical DIhydrocurcumIn 5mg
Supplier: Cayman Chemical 398235 MG
An ionizable cationic lipid has been used in the generation of LNPs encapsulating siRNA for use in vivo LNPs containing CL4H6 and encapsulating siRNA targeting Factor VII decrease hepatic levels of Factor VII in mice intravenous administration of LNPs containing CL4H6 and encapsulating a reporter protein selectively accumulate in the liver spleen and tumors over the lungs and kidneys as well as selectively accumulate in TAMs over tumor cells neutrophils and other leukocytes in a OS-RC-2 renal cancer mouse xenograft model LNPs containing CL4H6 and encapsulating siRNAs targeting and encapsulating siRNAs targeting mRNA encoding Stat3 and Hif-1a increase the levels of M1 macrophages in the tumor microenvironment and decrease tumor volume in the same model
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