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Invitrogen™ DIO3 Polyclonal Antibody
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Catalog No. PIPA5139919
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PIPA5139919 100 μL
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Catalog No. PIPA5139919 Supplier Invitrogen™ Supplier No. PA5139919
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: IRKHFLGRRR RGQPEPEVEL NSEGEEVPPD DPPICVSDDN RLCTLASLKA VWHGQKLDFF Highest antigen sequence indentity to the following orthologs: Rat - 29%, Mouse - 90%.

DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DIO3
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DIO3
Gene Accession No. P55073
Gene Alias 5DIII; D3; deiodinase, iodothyronine type III; deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; Dio3; DIOIII; I79_015795; iodothyronine deiodinase 3; iodothyronine deiodinase, placental type; Itdi3; LOW QUALITY PROTEIN: thyroxine 5-deiodinase; thyroxine 5-deiodinase; thyroxine deiodinase; thyroxine deiodinase type III (selenoprotein); TXDI3; Type 3 DI; type 3 iodothyronine selenodeiodinase; type III iodothyronine deiodinase; type-III 5' deiodinase; type-III 5'-deiodinase
Gene Symbols DIO3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DIO3. Recombinant protein control fragment (Product #RP-109364).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1735
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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