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Diphenyl phosphorochloridate, 97%

Catalog No. AAA1354630
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50 g
250 g
1000 g

CAS: 2524-64-3 | C12H10ClO3P | 268.633 g/mol

Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5',5'-triphosphate, guanosine-cytidine-5',5'-triphosphate, guanosine-uridine-5',5'-triphosphate, diguanosine-5',5'-diphosphate and diguanosine-5',5'-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5′,5′-triphosphate, guanosine-cytidine-5′,5′-triphosphate, guanosine-uridine-5′,5′-triphosphate, diguanosine-5′,5′-diphosphate and diguanosine-5′,5′-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.

Solubility
Immiscible with water.

Notes
Moisture sensitive. Incompatible with strong bases and strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 2524-64-3
Molecular Formula C12H10ClO3P
Molecular Weight (g/mol) 268.633
MDL Number MFCD00003030
InChI Key BHIIGRBMZRSDRI-UHFFFAOYSA-N
Synonym diphenyl chlorophosphate, diphenyl phosphorochloridate, diphenylchlorophosphate, phosphorochloridic acid, diphenyl ester, chlorodiphenyl phosphate, o,o-diphenyl chlorophosphate, chlorodiphenoxyphosphine oxide, diphenoxychlorophosphine oxide, diphenyl chlorophosphonate, diphenylphosphoric acid monochloride
PubChem CID 75654
IUPAC Name [chloro(phenoxy)phosphoryl]oxybenzene
SMILES C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl

Specifications

Density 1.296
Boiling Point 145°C to 147°C (1 mmHg)
Flash Point 113°C (235°F)
Refractive Index 1.55
Quantity 250 g
UN Number UN3265
Beilstein 654130
Sensitivity Moisture sensitive
Solubility Information Immiscible with water.
Formula Weight 268.64
Percent Purity 97%
Chemical Name or Material Diphenyl phosphorochloridate
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Hazard Category H314
Hazard Statement GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.
Precautionary Statement P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation Hazard Class: 8; Packaging Group: II
EINECSNumber 219-759-6
TSCA Yes
Recommended Storage Ambient temperatures

RUO – Research Use Only

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