Diphenyl phosphorochloridate, 97%

Description

CAS: 2524-64-3 | C12H10ClO3P | 268.633 g/mol

Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5',5'-triphosphate, guanosine-cytidine-5',5'-triphosphate, guanosine-uridine-5',5'-triphosphate, diguanosine-5',5'-diphosphate and diguanosine-5',5'-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5′,5′-triphosphate, guanosine-cytidine-5′,5′-triphosphate, guanosine-uridine-5′,5′-triphosphate, diguanosine-5′,5′-diphosphate and diguanosine-5′,5′-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.

Solubility
Immiscible with water.

Notes
Moisture sensitive. Incompatible with strong bases and strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 2524-64-3
• Molecular Formula: C12H10ClO3P
• Molecular Weight (g/mol): 268.633
• MDL Number: MFCD00003030
• InChI Key: BHIIGRBMZRSDRI-UHFFFAOYSA-N
• Synonym: diphenyl chlorophosphate, diphenyl phosphorochloridate, diphenylchlorophosphate, phosphorochloridic acid, diphenyl ester, chlorodiphenyl phosphate, o,o-diphenyl chlorophosphate, chlorodiphenoxyphosphine oxide, diphenoxychlorophosphine oxide, diphenyl chlorophosphonate, diphenylphosphoric acid monochloride
• PubChem CID: 75654
• IUPAC Name: [chloro(phenoxy)phosphoryl]oxybenzene
• SMILES: C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl

• Density: 1.296
• Boiling Point: 145°C to 147°C (1 mmHg)
• Flash Point: 113°C (235°F)
• Refractive Index: 1.55
• Quantity: 250 g
• UN Number: UN3265
• Beilstein: 654130
• Sensitivity: Moisture sensitive
• Solubility Information: Immiscible with water.
• Formula Weight: 268.64
• Percent Purity: 97%
• Chemical Name or Material: Diphenyl phosphorochloridate

Safety and Handling

Hazard Category	H314
Hazard Statement	GHS H Statement H314-H318 Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statement	P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Hazard Class: 8; Packaging Group: II
EINECSNumber	219-759-6
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only