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Apexbio Technology LLC Dp44mT 152095-12-0 50mg
Supplier: Apexbio Technology LLC B602150
Dp44mT (CAS 152095-12-0) is a small molecule iron chelator that selectively inhibits topoisomerase II a critical enzyme involved in chromosome segregation DNA replication and transcription In human breast cancer MDA-MB-231 cells Dp44mT exhibits a GI50 of approximately 100 nmol/L Experiments indicate that its cytotoxic effects are reduced in cells with diminished topoisomerase II expression underscoring target specificity Dp44mT treatment leads to the formation of covalent DNA-topoisomerase II complexes without affecting topoisomerase I or II These properties support its utility in studies on DNA damage enzymatic selectivity and mechanisms underlying cancer cell cytotoxicity
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