Invitrogen™ DLL1 (delta-like 1) Monoclonal Antibody (HMD1-5), Functional Grade, eBioscience™

Catalog No.	Quantity
50-145-69	500 μg

Catalog No. 50-145-69 Supplier Invitrogen™ Supplier No. 16576785

Description

Armenian Hamster Monoclonal Antibody

Description: The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis. This monoclonal antibody has been reported to have neutralizing activity. Applications Reported: This HMD1-5 antibody has been reported for use in functional assays. Applications Tested: This HMD1-5 antibody has been tested by flow cytometric analysis of Delta-like 1-transfected CHO cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Storage and ha...

Delta-like protein 1 (DLL1) is a transmembrane protein characterized by epidermal growth factor (EGF)-like repeats. It is a ligand for Notch receptor. It blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

Specifications

• Antigen: DLL1 (delta-like 1)
• Applications: Functional Assay
• Classification: Monoclonal
• Clone: HMD1-5
• Concentration: 1 mg/mL
• Conjugate: Functional Grade
• Formulation: PBS with no preservative; pH 7.2
• Gene: DLL1
• Gene Accession No.: Q61483
• Gene Alias: C-Delta-1; Delta; delta like canonical Notch ligand 1; delta like-1; DELTA1; delta-like 1; delta-like 1 (Drosophila); delta-like protein 1; DL1; Dll1; Dll1-derived cell-associated form; Dll1-EC; Dll1-IC; Dll1-intracellular form; Dll1-soluble form; Dll1-TMIC; Drosophila Delta homolog 1; H-Delta-1; LOW QUALITY PROTEIN: delta-like protein 1; OTTHUMP00000017690; UNQ146/PRO172
• Gene Symbols: DLL1
• Host Species: Armenian Hamster
• Purification Method: Affinity chromatography
• Quantity: 500 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 13388
• Target Species: Mouse
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG