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Cayman Chemical Indole-3-carbInol 5g
SDP

Supplier:  Cayman Chemical 113255 G

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FK-506 s a potent mmunosuppressant that forms a hgh affnty complex (K 0 2 nM) wth FK-506 bndng proten 12 (FKBP12) Ths complex nhbts the actvty of the calcum/calmoduln-dependent proten phosphatase calcneurn leadng to dsrupton of T-cell actvaton 13842 SLF s a cell-permeable analog of FK-506 that bnds tghtly to FKBP but lacks the ablty to nhbt calcneurn 13706 By tself SLF does not exhbt a sgnfcant cellular response However homodmers of SLF or heterodmers wth another proten lgand provde a method to promote the dmerzaton of lgand-specfc fuson protens to nduce sgnalng events wthn a cellular envronment 1370113706 For example SLF monomers connected wth a 10-atom lnker actvates Fas sgnalng va Fas-FKBP fuson protens wth an EC50 of 6 nM 13701

Catalog No. 50-295-4013


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