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  5. Tocris Bioscience™ DMB

Tocris Bioscience™ DMB

Catalog No. 887410
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Catalog No. Quantity
88-741-0 10 mg
88-745-0 50 mg
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Catalog No. 88-741-0 Supplier Tocris Bioscience™ Supplier No. 8874/10
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Description

GSDMD (Gasdermin D) agonist, activator of pyroptosis, also GLP-1R agonist

DMB is a Gasdermin D (GSDMD) agonist (EC50 = 0.7 mM). DMB directly bound to GSDMD (KD = 1.1 mM). DMB activates GSDMD pore formation and pyroptosis without cleaving GSDMD. In vivo, DMB suppresses tumor growth without harming GSDMD-expressing immune cells in mouse tumor models. DMB is also an agonist of glucagon-like peptide 1 receptor. DMB is orally bioavailable.

Specifications

Chemical Name or Material 6,7-Dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine
CAS 281209-71-0
Quantity 10 mg
Target Inflammasomes Activators
Molecular Formula C13H15Cl2N3O2S
Purity 98%
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