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Invitrogen™ DMP1 Polyclonal Antibody
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Catalog No. PIPA547621
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100 μg
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PIPA547621 100 μg
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Catalog No. PIPA547621 Supplier Invitrogen™ Supplier No. PA547621
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Description

Sheep Polyclonal Antibody

In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant human DMP-1 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DMP1
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative; pH 7.4
Gene Dmp1
Gene Accession No. O55188
Gene Alias AG1; ARHP; ARHR; AV020965; dentin matrix acidic phosphoprotein 1; dentin matrix protein 1; DENTMAT; Dmp; DMP 1; Dmp1; DMP-1; MGC130441; PP; serine rich acidic phosphoprotein
Gene Symbols Dmp1
Host Species Sheep
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse DMP-1 Leu17-Tyr503.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13406
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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