DNAL1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-0497	150 μL

Catalog No. 50-173-0497 Supplier Proteintech Group Inc Supplier No. 158091AP150UL

Description

Rabbit Polyclonal Antibody

DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.

Specifications

• Antigen: DNAL1
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.15 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: DNAL1
• Gene Accession No.: Q05A62, Q4LDG9
• Gene Alias: C14orf168, DNAL1, Dynein light chain 1, axonemal
• Gene Symbols: Dnal1
• Host Species: Rabbit
• Immunogen: DNAL1 Fusion Protein Ag8545
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 105000, 685664, 83544
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG