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DNMT3B Polyclonal Antibody, Active Motif™
SDP

Catalog No. p-7188589
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50-199-2943 10 μL
50-199-2942 100 μL
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Catalog No. 50-199-2943 Supplier Active Motif Supplier No. 39900
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Description

Rabbit Polyclonal Antibody

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Specifications

Antigen DNMT3B
Applications Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Dnmt3b
Gene Accession No. O88509
Gene Alias DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase 3 beta; DNA methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA methyltransferase MmuIIIB; DNA MTase HsaIIIB; DNA MTase MmuIIIB; Dnmt3; DNMT3B; ICF; ICF1; M.HsaIIIB; m.MmuIIIB; MGC1090; MmuIIIB
Gene Symbols Dnmt3b
Host Species Rabbit
Immunogen This DNMT3B antibody was raised against a recombinant protein corresponding to amino acids 1-218 of mouse DNMT3B.
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13436
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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