Invitrogen™ DOCK11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537152

Catalog No. PIPA537152

Description

This antibody detects endogenous protein at a molecular weight of 238 kDa. Purity is >95% by SDS-PAGE.

Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cell-cell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.

Specifications

• Antigen: DOCK11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DOCK11
• Gene Alias: 5033414A21Rik; 8030476J24; ACG; activated Cdc42-associated guanine nucleotide exchange factor; Activated Cdc42-associated guanine nucleotide exchange factor, ACG; bB128O4.1; bB128O4.1.1 (novel protein); dedicator of cytokinesis 11; dedicator of cytokinesis protein 11; Dock11; DOCK-11; sph238; spleen specific 238 kDa protein with PH domain; ZIZ2; Zizimin 2; zizimin2; Zizimin-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 139818, 313438, 75974
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: A2AF47, Q5JSL3
• Gene Symbols: DOCK11
• Immunogen: A synthetic peptide corresponding to residues in human DOCK11.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov