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Invitrogen™ DOCK11 Polyclonal Antibody
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Catalog No. PIPA537152
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100 μL
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PIPA537152 100 μL
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Catalog No. PIPA537152 Supplier Invitrogen™ Supplier No. PA537152
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 238 kDa. Purity is >95% by SDS-PAGE.

Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cell-cell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DOCK11
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene DOCK11
Gene Accession No. A2AF47, Q5JSL3
Gene Alias 5033414A21Rik; 8030476J24; ACG; activated Cdc42-associated guanine nucleotide exchange factor; Activated Cdc42-associated guanine nucleotide exchange factor, ACG; bB128O4.1; bB128O4.1.1 (novel protein); dedicator of cytokinesis 11; dedicator of cytokinesis protein 11; Dock11; DOCK-11; sph238; spleen specific 238 kDa protein with PH domain; ZIZ2; Zizimin 2; zizimin2; Zizimin-2
Gene Symbols DOCK11
Host Species Rabbit
Immunogen A synthetic peptide corresponding to residues in human DOCK11.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 139818, 313438, 75974
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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