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DOK1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 178221AP150UL

Description
Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF.Specifications
DOK1 | |
Polyclonal | |
Unconjugated | |
DOK1 | |
Docking protein 1, DOK1, p62(dok), P62DOK, pp62 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
1796 | |
-20°C | |
Liquid |
Western Blot | |
0.41 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q99704 | |
DOK1 | |
DOK1 Fusion Protein Ag12189 | |
150 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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