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DOK1 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501731817 Shop All Proteintech Group Inc Products
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50-173-1817 150 μL
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Catalog No. 50-173-1817 Supplier Proteintech Group Inc Supplier No. 178221AP150UL
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Description

Rabbit Polyclonal Antibody

Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF.

Specifications

Antigen DOK1
Applications Western Blot
Classification Polyclonal
Concentration 0.41 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene DOK1
Gene Accession No. Q99704
Gene Alias Docking protein 1, DOK1, p62(dok), P62DOK, pp62
Gene Symbols DOK1
Host Species Rabbit
Immunogen DOK1 Fusion Protein Ag12189
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1796
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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