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DOK2 Mouse anti-Canine, Human, Mouse, Rat, Clone: OTI2D10, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA503381

Catalog No. 50-167-4287


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Description

Description

Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.
Specifications

Specifications

DOK2
Monoclonal
0.43 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
O60496, O70469
p56DOK, p56dok-2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
13449, 290361, 486133, 9046
Western Blot
OTI2D10
Unconjugated
DOK2
Liquid
Dok2
Full length human recombit protein of human DOK2 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Mouse, Rat
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