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Invitrogen™ DOK6 Polyclonal Antibody
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Catalog No. PIPA5115138
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PIPA5115138 100 μL
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Catalog No. PIPA5115138 Supplier Invitrogen™ Supplier No. PA5115138
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DOK6.

DOK-6 (docking protein 6), is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway. (Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072-81. Epub 2004 Jul 30. It is also known as DOK6, HsT3226, MGC20785 or IRS. 0.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DOK6
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene Dok6
Gene Accession No. Q2MHE5, Q6PKX4
Gene Alias Docking protein 6; DOK5L; Dok6; Dok-6; Downstream of tyrosine kinase 6; downstream of tyrosine kinases 6; HsT3226; RGD1564376
Gene Symbols Dok6
Host Species Rabbit
Immunogen A synthesized peptide derived from human DOK6(Accession Q6PKX4), corresponding to amino acid residues E110-T160.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 220164, 623279
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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