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Invitrogen™ Doublecortin Monoclonal Antibody (01), Invitrogen™

Catalog No. PIMA543489
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PIMA543489 50 μL
PIMA543039 100 μL
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Catalog No. PIMA543489 Supplier Invitrogen™ Supplier No. MA543489
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Description

Mouse Monoclonal Antibody

Specificity: Human Doublecortin/DCX

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Doublecortin
Applications Immunocytochemistry
Classification Monoclonal
Clone 01
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene DCX
Gene Accession No. O43602
Gene Alias DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
Gene Symbols DCX
Host Species Mouse
Immunogen Recombinant Human Doublecortin/DCX Protein.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1641
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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