ABclonal Technology Doublecortin Rabbit mAb

Supplier:  ABclonal Technology A23501100UL

This gene encodes a protein from the doublecortin family containing two doublecortin domains that bind microtubules It plays a key role in cortical neuron migration during development by regulating microtubule organization and stability The protein interacts with LIS1 the regulatory subunit of platelet-activating factor acetylhydrolase which is essential for microtubule function in the cortex Mutations in this gene disrupt neuronal migration leading to cortical layering defects and conditions such as epilepsy cognitive disability double cortex syndrome in females and lissencephaly (smooth brain syndrome) in males Multiple transcript variants producing different isoforms have been identified for this gene

Catalog No. 50-000-06039