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Apexbio Technology LLC Gambogic Acid 2752-65-0 10mg
Supplier: Apexbio Technology LLC A342410
Gambogic Acid (CAS 2752-65-0) is a natural cytotoxic compound known to induce apoptosis through interactions with multiple apoptotic regulatory proteins It primarily targets anti-apoptotic Bcl-2 family members including Bcl-XL Bcl-2 Bcl-W Bcl-B Bfl-1 and Mcl-1 competitively binding to their BH3 domains and disrupting their suppression of mitochondrial pro-apoptotic factors It activates caspase-driven apoptotic pathways with EC50 values between 0 78-1 64 M Gambogic Acid demonstrates selective toxicity against cancer cell lines such as human gastric carcinoma MGC-803 cells and U266 multiple myeloma cells and inhibits tumor growth and angiogenesis in various in vivo xenograft models suggesting potential value for cancer biology research
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