Thermo Scientific Chemicals Doxycycline hydrochloride, 20 mg/ml in distilled water, sterile-filtered

Description

Doxycycline hydrochloride, CAS # 10592-13-9, is the hydrochloride salt form of doxycycline that shows antibacterial and antimalarial activities. | CAS: 10592-13-9 | C22H25ClN2O8 | 480.90 g/mol

Doxycycline hydrochloride, is used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Doxycycline hydrochloride is a compound that shows antibacterial and antimicrobial activities against several species, including Pseudomonas aeruginosa, Plasmodium falciparum, and Escherichia coli. It is also a bacteriostatic

• It can block the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis

Application

• It is used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and eliminate Ixodes scapularis ticks

• Doxycycline hydrochloride is also considered to be a broad-spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase, in wound healing and tissue remodeling studies. Due to this activity, it can inhibit angiogenesis and reduce lung metastases

Specifications

Chemical Identifiers

• CAS: 10592-13-9
• Molecular Formula: C22H25ClN2O8
• Molecular Weight (g/mol): 480.90
• MDL Number: MFCD03427564
• InChI Key: VLUQVUWDECWBTL-UQVCFKGQSA-N
• PubChem CID: 54706018
• IUPAC Name: (1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride
• SMILES: [Cl-].C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H]([NH+](C)C)C(=O)\C(=C(/N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12

• Type: Doxycycline Hydrochloride
• Physical Form: Liquid
• Concentration: 20mg/mL in distilled water
• Quantity: 50 mL
• Solubility Information: Soluble in water.
• Chemical Name or Material: Doxycycline hydrochloride, sterile-filtered

Safety and Handling

Hazard Category	H335
Hazard Statement	GHS H Statement H350 May cause cancer.
Precautionary Statement	GHS P Statement P281-P201-P202-P308+P313-P405-P501a Use personal protective equipment as required. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
EINECSNumber	234-198-7
TSCA	No
storageNote1	−30° to −10°C
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only