Doxycycline monohydrate

Description

Doxycycline monohydrate, CAS # 17086-28-1, is the hydrated form of the tetracycline class antibiotic doxycycline. | CAS: 17086-28-1 | C22H26N2O9 | 462.455 g/mol

Doxycycline monohydrate acts as an antibiotic, antimicrobial agent and a matrix metalloproteinase inhibitor. In addition to this, it inhibits the bacterial protein synthesis by preventing the interaction of aminoacyl-tRNA and the bacterial ribosome.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Doxycycline monohydrate is a semi-synthetic tetracycline antibiotic with broad-spectrum activity
• It is a tetracycline with the 5beta-hydrogen group replaced by a hydroxy group
• Doxycycline monohydrate acts by binding the 30S ribosomal subunit and preventing polypeptide formation
• Doxycycline monohydrate may also act on the 50S ribosomal subunit, is a known inhibitor of collagenases, and has anti-inflammatory properties

Application

• Doxycycline can be used for study of cancers, infections, and antibiotic resistance in laboratory settings
• Doxycycline can be used experimentally to control TET genes and induce expression of genes of interest in vitro

Specifications

Chemical Identifiers

• CAS: 17086-28-1
• Molecular Formula: C22H26N2O9
• Molecular Weight (g/mol): 462.455
• MDL Number: MFCD02682958
• InChI Key: FZKWRPSUNUOXKJ-CVHRZJFOSA-N
• PubChem CID: 54684461
• IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrate
• SMILES: CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O

• Type: Doxycycline Monohydrate
• Physical Form: Powder
• Melting Point: 167°C to 168°C
• Color: Yellow
• Quantity: 5 g
• Merck Index: 14,3440
• Solubility Information: Soluble in ethanol or methanol; Sparingly soluble in water;Soluble in dilute acids,alkali hydroxides and dimethyl sulfoxide.
• Formula Weight: 462.46 (444.44 Anhydrous)
• Chemical Name or Material: Doxycycline monohydrate

Safety and Handling

Hazard Category	H361d
Hazard Statement	GHS H Statement H302 Harmful if swallowed.
Precautionary Statement	P201-P202-P281-P308+P313-P501c
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only