DR3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 553971AP150UL

Catalog No. 50-173-6138

Description

This antibody can recognize all the isoform of TNFRSF25.

DR3/TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of DR3/TNFRSF25 in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predomitly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

Specifications

• Antigen: DR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFRSF25
• Gene Alias: APO 3, APO3, DDR3, Death receptor 3, DR3, LARD, Protein WSL, Protein WSL 1, TNFRSF12, TNFRSF25, TR3, TRAMP, WSL, WSL 1, WSL LR, WSL1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 85030, 8718
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q93038
• Gene Symbols: Tnfrsf25
• Immunogen: Peptide
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG