DR6 Mouse anti-Human, Clone: 3C2D10, Proteintech

Catalog No.	Quantity
50-173-7161	150 μL

Catalog No. 50-173-7161 Supplier Proteintech Group Inc Supplier No. 667541IG150UL

Description

Mouse Monoclonal Antibody

DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.

Specifications

• Antigen: DR6
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 3C2D10
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: TNFRSF21
• Gene Accession No.: O75509
• Gene Alias: BM 018, CD358, Death receptor 6, DR6, TNFRSF21
• Gene Symbols: TNFRSF21
• Host Species: Mouse
• Immunogen: DR6 Fusion Protein Ag14327
• Purification Method: Protein G
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 27242
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1