DUSP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, liquid, OriGene

Catalog No.	Quantity
50-168-4749	100 μL

Catalog No. 50-168-4749 Supplier OriGene Supplier No. TA890036

Description

Rabbit Polyclonal Antibody

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Specifications

• Antigen: DUSP1
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene: DUSP1
• Gene Accession No.: P28562, P28563, Q64623
• Gene Alias: CL100, HVH1, MKP-1, MKP1, PTPN10
• Gene Symbols: Dusp1
• Host Species: Rabbit
• Immunogen: Recombit protein of human DUSP1
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 114856, 1843, 19252
• Target Species: Human, Mouse, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG