DUSP10 Monoclonal Antibody (OTI2E3), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-1226	100 μL

Catalog No. 50-168-1226 Supplier OriGene Supplier No. TA806723

Description

Mouse Monoclonal Antibody

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

Specifications

• Antigen: DUSP10
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2E3
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: DUSP10
• Gene Accession No.: Q9Y6W6
• Gene Alias: MKP-5, MKP5
• Gene Symbols: DUSP10
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 180-482 of human DUSP10 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11221
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b