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  6. E-selectin /CD62E Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech 

E-selectin /CD62E Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
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Catalog No. 501733142 Shop All Proteintech Group Inc Products
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50-173-3142 150 μL
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Catalog No. 50-173-3142 Supplier Proteintech Group Inc Supplier No. 208941AP150UL
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Description

Rabbit Polyclonal Antibody

Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signalling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.

Specifications

Antigen E-selectin /CD62E
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.15 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SELE
Gene Accession No. P16581, P98105, Q00690
Gene Alias CD62E, ELAM, ELAM 1, ELAM1, ESEL, E-selectin, LECAM2, SELE, selectin E
Gene Symbols SELE
Host Species Rabbit
Immunogen E-selectin /CD62E Fusion Protein Ag14944
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20339, 25544, 6401
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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