E-selectin /CD62E Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-3142	Proteintech Group Inc 208941AP150UL	150 μL

Description

Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signalling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.

Specifications

• Antigen: E-selectin /CD62E
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P16581, P98105, Q00690
• Gene ID (Entrez): 20339, 25544, 6401
• Immunogen: E-selectin /CD62E Fusion Protein Ag14944
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SELE

• Concentration: 0.15 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CD62E, ELAM, ELAM 1, ELAM1, ESEL, E-selectin, LECAM2, SELE, selectin E
• Gene Symbols: SELE
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody