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  6. Invitrogen™ E-selectin Recombinant Rabbit Monoclonal Antibody (40), Invitrogen™

Invitrogen™ E-selectin Recombinant Rabbit Monoclonal Antibody (40), Invitrogen™

Catalog No. p-7240396
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PIMA543527 50 μL
PIMA543137 100 μL
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Catalog No. PIMA543527 Supplier Invitrogen™ Supplier No. MA543527
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Human E-selectin/SELE/CD62E

Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
TRUSTED_SUSTAINABILITY

Specifications

Antigen E-selectin
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 40
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene SELE
Gene Accession No. P16581
Gene Alias CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Gene Symbols SELE
Host Species Rabbit
Immunogen Recombinant Human CD62E protein.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6401
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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