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Invitrogen™ E2F1 Monoclonal Antibody (KH95)
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Catalog No. 321400
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Catalog No. Quantity
32-140-0 100 μg
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Catalog No. 32-140-0 Supplier Invitrogen™ Supplier No. 321400
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Description

Mouse Monoclonal Antibody

E2F1 Monoclonal Antibody for Western Blot, IHC, IP, ChIP

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen E2F1
Applications ChIP Assay, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone KH95
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene E2F1
Gene Accession No. O09139, Q01094, Q61501
Gene Alias E2F transcription factor 1; E2F1; E2F-1; mKIAA4009; PBR3; PRB-binding protein E2F-1; RBAP1; RBAP-1; RBBP3; RBBP-3; RBP3; Retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; Transcription factor E2F1
Gene Symbols E2F1
Host Species Mouse
Immunogen Recombinant human E2F-1 protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13555, 1869, 399489
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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