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Invitrogen™ E6AP Recombinant Rabbit Monoclonal Antibody (19H14L13)

Catalog No. 703785
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Catalog No. Quantity
70-378-5 100 μg
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Catalog No. 70-378-5 Supplier Invitrogen™ Supplier No. 703785
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Pig, Sheep, Bovine. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. UBE3A also plays an important role in the regulation of the circadian clock. Defects in UBE3A are a cause of Angelman syndrome (AS).
TRUSTED_SUSTAINABILITY

Specifications

Antigen E6AP
Applications Western Blot
Classification Recombinant Monoclonal
Clone 19H14L13
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2-7.4
Gene UBE3A
Gene Accession No. Q05086
Gene Alias 4732496B02; 5830462N02Rik; A130086L21Rik; ANCR; AS; CTCL tumor antigen se37-2; E6AP; E6-AP; E6-AP ubiquitin protein ligase; E6AP ubiquitin-protein ligase; EPVE6AP; FLJ26981; HECT-type ubiquitin transferase E3A; HPVE6A; human papilloma virus E6-associated protein; human papillomavirus E6-associated protein; mKIAA4216; oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; UBE3A; ubiquitin conjugating enzyme E3A; ubiquitin protein ligase E3A; ubiquitin-protein ligase E3A
Gene Symbols UBE3A
Host Species Rabbit
Immunogen Protein corresponding to human E6AP [aa50-aa200].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7337
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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