EBI3 Mouse anti-Human, Porcine, Rat, Clone: 1F3H10, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 663541IG150UL

Catalog No. 50-173-6785

Description

EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.

Specifications

• Antigen: EBI3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q14213
• Gene Symbols: EBI3
• Immunogen: EBI3 Fusion Protein Ag3051
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Pig, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: 1F3H10
• Conjugate: Unconjugated
• Gene: EBI3
• Gene Alias: EBI3, EBV induced gene 3 protein, Epstein Barr virus induced 3, IL 27 subunit beta, IL 27B, IL27B, Interleukin 27 subunit beta
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100522599, 10148, 680609
• Content And Storage: -20°C
• Form: Liquid