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Invitrogen™ EBI3 Polyclonal Antibody
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Catalog No. PIPA5111241
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100 μL
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PIPA5111241 100 μL
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Catalog No. PIPA5111241 Supplier Invitrogen™ Supplier No. PA5111241
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SPVSFIATYR LGMAARGHSW PCLQQTPTST SCTITDVQLF SMAPYVLNVT AVHPWGSSSS FVPFITEHII KPDPPEGVRL SPLAERQLQV QWEPPGSWPF PEIFSLKYWI RYKRQGAARF HRVGPIEATS FILRAV Highest antigen sequence indentity to the following orthologs: Mouse - 63%, Rat - 63%.

EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein of the hematopoietin receptor family. It plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo, which may be mediated through the control of iNKT cell function. EBI3 dimerizes with p28 and p35 subunits of IL-12 to form new proteins IL-27 and IL-35, respectively. IL-27 is an early product of activated antigen presenting cell that is produced upon TLR ligation. It negatively regulates Th17 cell differentiation. EBI3 is widely expressed and its expression in dendritic cell is transcriptionally regulated by TLR signaling via MyD88 and NF-kappaB during innate immune responses preceding cytokine driven Th cell development. EBI3 signal inhibits delayed-type hypersensitivity responses by suppressing IL-17 production and inducing IL-10 hyperproduction. EBI3 may play a novel role in controlling tumor metastasis via lung CD8+ T cells, and its deficiency is associated with a diminished production of Th2 cytokines which are known to regulate allergic airway inflammation in asthma. Targeted deletion of EBI3 protects mice from lung metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EBI3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene EBI3
Gene Accession No. Q14213
Gene Alias cytokine receptor; EBI3; EBI-3; EBV-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus induced gene 3; Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor); epstein-Barr virus-induced gene 3 protein; Epstein-Barr virus-induced gene 3 protein homolog; IL-27; IL27 subunit; IL-27 subunit beta; IL27B; IL-27B; IL35 subunit; interleukin-27 subunit beta
Gene Symbols EBI3
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human EBI3. Recombinant protein control fragment (Product #RP-89546).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10148
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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