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Tocris Bioscience™ Echistatin, alpha1 isoform
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Catalog No. 3202100U
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100 μg
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Catalog No. Quantity
32-021-00U 100 μg
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Catalog No. 32-021-00U Supplier Tocris Bioscience™ Supplier No. 3202/100U
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Description

αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor

Echistatin, α1 isoform is a potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro.

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