Invitrogen™ ECM1 Recombinant Rabbit Monoclonal Antibody (030)

Catalog No.	Quantity
PIMA530352	100 μL

Catalog No. PIMA530352 Supplier Invitrogen™ Supplier No. MA530352

Description

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Human ECM1.

ECM1, also referred to as extracellular matrix protein 1, is a protein that plays a significant role in regulating extracellular matrix organization and cell adhesion. It is expressed in various tissues, including the skin, lung, and liver, and is involved in the development and progression of several diseases, including cancer and dermatological disorders. The protein interacts with several extracellular matrix proteins, such as collagen and fibronectin, and is involved in the regulation of cell proliferation, migration, and invasion. ECM1 is also involved in endochondral bone formation, angiogenesis, and tumor biology. It interacts with various extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae, and certain viscera. Different isoforms of ECM1 have been described in alternatively spliced transcript variants. Diseases associated with ECM1 include Lipoid Proteinosis Of Urbach And Wiethe and Lichen Sclerosus Et Atrophicus.

Specifications

• Antigen: ECM1
• Applications: ELISA
• Classification: Recombinant Monoclonal
• Clone: 030
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: ECM1
• Gene Accession No.: Q16610
• Gene Alias: AI663821; ECM1; Extracellular matrix protein 1; LOW QUALITY PROTEIN: extracellular matrix protein 1; extracellular matrix protein 1; p85; RP11-54A4.6; Secretory component p85; testicular tissue protein Li 61; URBWD
• Gene Symbols: ECM1
• Host Species: Rabbit
• Immunogen: Recombinant Human ECM1 Protein.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1893
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG