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Invitrogen™ ECSIT Polyclonal Antibody
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Catalog No. PIPA5109674
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100 μL
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PIPA5109674 100 μL
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Catalog No. PIPA5109674 Supplier Invitrogen™ Supplier No. PA5109674
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SEQSLVPSPP EPRQRPTKAL VPFEDLFGQA PGGERDKASF LQTVQKFAEH SVRKRGHIDF IYLALRKMRE YGVERDLAVY NQLLNIFPKE VFRPRNIIQR IFVHYPRQQE CGIAVLEQME NHGVMPNKET EFLLIQIFGR KSYPMLKLVR LKLWFPRFMN VNPFPVPRDL PQDPVELAMF GLRHMEPDLS ARVTIYQVPL PKDSTGAADP PQPHIVGSGR DAGGVEPLLP DAAGPGVCEE WLGQLRV.

Activation of NF-kappa-B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ECSIT
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 5.44 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ECSIT
Gene Accession No. Q5XIC2, Q9BQ95, Q9QZH6
Gene Alias Ecsit; ECSIT homolog; ECSIT homolog (Drosophila); ECSIT signalling integrator; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved; Protein SITPEC; signaling intermediate in Toll pathway-evolutionarily conserved; Sitpec
Gene Symbols ECSIT
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 50-296 of human ECSIT (NP_001135936.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26940, 300447, 51295
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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