Invitrogen™ EDG3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533495

Catalog No. PIPA533495

Description

Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Marmoset (95%). For IHC(P), use proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Specifications

• Antigen: EDG3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: S1PR3
• Gene Alias: AI132464; cardiac sphingosine-1-phosphate specific receptor; EDG3; EDG-3; Edg3l; Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; Lpb3; Lysophospholipid receptor B3; MGC71696; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; S1P receptor S1P3; S1p3; S1PR3; sphingosine; Sphingosine 1-phosphate receptor 3; sphingosine 1-phosphate receptor Edg-3; sphingosine-1-phosphate receptor 3
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1903
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q99500
• Gene Symbols: S1PR3
• Immunogen: Synthetic 19 amino acid peptide from N-Terminus of human EDG3 / S1P3.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov