Invitrogen™ EDG6 Monoclonal Antibody (1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA112681

Catalog No. 01-674-034

Description

A suggested positive control for this product is RH7777 cells transfected with EDG6 proteinlysate.

EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG6 (S1P4) receptor is the sphingosine 1-phosphate receptor-4 (S1P4).

Specifications

• Antigen: EDG6
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: S1PR4
• Gene Alias: Edg6; EDG-6; Endothelial differentiation G-protein coupled receptor 6; endothelial differentiation G-protein-coupled receptor 6; endothelial differentiation, G protein coupled receptor 6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6; LPC1; Lysophospholipid receptor C1; S1P receptor 4; S1P receptor Edg-6; S1P(4) receptor; S1p4; S1PR4; SLP4; sphingosine 1-phosphate receptor 4; Sphingosine 1-phosphate receptor Edg-6; sphingosine-1-phosphate receptor 4
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 8698
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Western Blot
• Clone: 1
• Formulation: PBS with 0.08% sodium azide
• Gene Accession No.: O95977
• Gene Symbols: S1PR4
• Immunogen: Synthetic peptide corresponding to the C-terminal of EDG6.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov