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Invitrogen™ EEA1 Monoclonal Antibody (F.43.1)
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Catalog No. PIMA514794
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100 μL
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PIMA514794 100 μL
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Catalog No. PIMA514794 Supplier Invitrogen™ Supplier No. MA514794
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

Early endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains, reminiscent of those found in nucleic acid binding proteins, are located in the amino and carboxyl-terminal domains of EEA1. The carboxyl-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EEA1
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone F.43.1
Concentration 44 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 0.15M NaCl, 100 μg/mL BSA, 50% glycerol and <0.02% sodium azide, pH 7.5
Gene EEA1
Gene Accession No. Q15075, Q8BL66
Gene Alias A430109M19Rik; B230358H09Rik; Early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain-containing protein 2
Gene Symbols EEA1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding Ser70 of human EEA1 protein.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216238, 314764, 8411
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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