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Invitrogen™ EEA1 Polyclonal Antibody
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Catalog No. PIPA587460
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100 μL
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PIPA587460 100 μL
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Catalog No. PIPA587460 Supplier Invitrogen™ Supplier No. PA587460
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LKAAVEQEKR NQQILKDQVK KEEEELKKEF IEKEAKLHSE IKEKEVGMKK HEENEAKLTM QITALNENLG TVKKEWQSSQ RRVSELEKQT DDLRGEIAVL EATVQNNQDE RRALLERCLK GEGEIEKLQT KVLELQRKLD NTTAAVQELG RENQSLQIKH TQALNRKWAE DNEVQNCMAC GKGFSVTVRR HHCRQCGNIF CAECSAKNAL TPSSKKPVRV CDACFNDLQG; Positive Samples: U-87MG, HT-1080, LO2, Mouse kidney, Mouse lung, Rat brain; Cellular Location: Cytoplasm, Early endosome membrane, Peripheral membrane protein.

Early endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains, reminiscent of those found in nucleic acid binding proteins, are located in the amino and carboxyl-terminal domains of EEA1. The carboxyl-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EEA1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene EEA1
Gene Accession No. Q15075, Q8BL66
Gene Alias A430109M19Rik; B230358H09Rik; Early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain-containing protein 2
Gene Symbols EEA1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1182-1411 of human EEA1 (NP_0035572).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216238, 314764, 8411
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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