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  5. Tocris Bioscience™ EED 226

Tocris Bioscience™ EED 226
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Catalog No. 776210
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10 mg
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Catalog No. Quantity
77-621-0 10 mg
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Catalog No. 77-621-0 Supplier Tocris Bioscience™ Supplier No. 7762/10
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Description

Potent and selective EED inhibitor

EED 226 is a potent (IC50 = 23.4 nM) and selective EED inhibitor. It inhibits PRC2 activity by binding to the H3K27me3 pocket of EED. The compound shows selectivity for PRC2 complex over protein methyltransferases, kinases, and other protein classes. In vitro, EED 226 regulates histone H3K27 methylation and PRC2 target gene expression. In vivo, it induces tumor regression in a mouse xenograft model. EED 226 is orally bioavailable.

Specifications

Chemical Name or Material N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CAS 2083627-02-3
Quantity 10 mg
Target EED
Molecular Formula C17H15N5O3S
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