Invitrogen™ Human EIF2AK1 (HRI), GST Tag Recombinant Protein

Catalog No.	Quantity
PV5856	10 μg

Catalog No. PV5856 Supplier Invitrogen™ Supplier No. PV5856

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme. The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands and kinase activity is induced by low levels of heme and inhibited by the presence of heme.

Specifications

• Accession Number: Q9BQI3
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris with no preservative
• Gene ID (Entrez): 27102
• Molecular Weight (g/mol): 98.6 kDa
• Name: Human EIF2AK1 (HRI), GST Tag
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; he; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; hemin-sensitive initiation factor 2a kinase; hemin-sensitive initiation factor 2-alpha kinase; Hri; KIAA1369; PRO1362
• Common Name: HRI
• Gene Symbol: EIF2AK1
• Kinase Family: PEK Kinase Family
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Assay Entry: Biochemical terbium phospho-specific activity
• Kinase Group: Ser⁄Thr Kinases: Other
• Shipping Condition: Dry Ice
• System Compatibility: LanthaScreen™
• Tag Position: N-Terminal
• Target Entry: EIF2AK1
• Target Gene: EIF2AK1
• Expression System: Baculovirus
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Full Length
• Form: Liquid
• Protein Subtype: Serine/Threonine Kinases
• Research Category: Signal Transduction