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EIF4B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 179171AP150UL

Encompass_Preferred

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Catalog No. 50-173-1873


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Description

Description

eIF4B is a multidomain eukaryotic translation initiation factor with a range of activities. It contains one RRM (RNA recognition) domain, a consensus RNA-binding site (RNP-CS) near the N terminus, and a central domain rich in aspartic acid, arginine, tyrosine, and glycine (DRYG). The DRYG domain of eIF4B helps in self-association and interaction with the p170 subunit of eIF3. eIF4B binds to both mRNA and 18S ribosomal RNA and thus acts as a bridge between the mRNA and the 40S ribosomal subunit during translation initiation. The ATPase and RNA helicase activity of the DEAD box protein eIF4A is stimulated by eIF4B and thus functions in close association with eIF4F a heterotrimeric protein that binds to mRNA cap structure and unwinds inhibitory secondary structure in the 5′ untranslated region of eucaryotic mRNAs in an ATP-dependent manner. Ubiquitous expression is seen in most of the tissues.
Specifications

Specifications

EIF4B
Polyclonal
Unconjugated
EIF4B
EIF 4B, EIF4B, PRO1843
Rabbit
Antigen Affinity Chromatography
RUO
1975, 300253, 75705
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
0.45 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P23588, Q8BGD9
Eif4b
EIF4B Fusion Protein Ag12325
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
SDS
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Product Certifications
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