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Apexbio Technology LLC SB408124 288150-92-5 5mg
SDP

Supplier:  Apexbio Technology LLC B21635

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SB408124 (CAS 288150-92-5) is a non-peptide antagonist of the orexin-1 receptor (OX1) It displays receptor selectivity exhibiting approximately 50-fold greater affinity for OX1 compared to OX2 receptors in humans with reported Ki values of 27 nM (membrane preparations) and 57 nM (whole-cell assays) Experimental studies using primary cultured rat astrocytes indicate that SB408124 pretreatment can attenuate orexin-A-mediated stimulation of cAMP production In vivo rat models demonstrate that co-administration with orexin-A prevents reductions in vasopressin elevations induced by histamine or hyperosmotic challenge SB408124 serves as a tool compound in research exploring the physiological roles of OX1 receptors in neuroendocrine and cellular signaling pathways

Catalog No. 50-000-62428


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