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MilliporeSigma™ 5-Lipoxygenase, Human, Recombinant Protein, S. fruigiperda

Catalog No. 437996500U Shop All MilliporeSigma Products
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43-799-6500U 500 U
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Catalog No. 43-799-6500U Supplier MilliporeSigma™ Supplier No. 437996500U
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Description

Recombinant, human 5-Lipoxygenase expressed in S. fruigiperda insect cells using a baculovirus overexpression system. 5-LO catalyzes the formation of 5(S)-HpETE from arachidonic acid and its subsequent conversion to leukotriene A4. It is localized in the cytosol of resting human and rat peripheral blood neutrophils, whereas it is found in the nucleus in rat basophilic leukemia cells and human alveolar macrophages. Upon stimulation of the cell, 5-LO translocates to the nuclear membrane where it is found in association with 5-LO activating protein (FLAP) and with the 85kDa cPLA2.
TRUSTED_SUSTAINABILITY

Specifications

Formulation In 100mM Tris containing 5mM EGTA, pH 8.0.
Quantity 500 U
Source S. fruigiperda
Immunogen 5-Lipoxygenase
Storage Requirements Following initial thaw, aliquot and freeze (−70°C).
Regulatory Status RUO
Species Human
Recombinant Recombinant
Form Liquid
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