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MilliporeSigma™ Chemicon™ Recombinant Human Pigment Epithelium Derived Factor Protein

Catalog No. GF134 Shop All MilliporeSigma Products
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GF134 10 μg
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Description

a 50 kDa secreted protein in conditioned medium from cultured fetal human retinal pigment epithelium (RPE) cells

Pigment epithelium-derived factor (PEDF) was first identified as a 50 kDa secreted protein in conditioned medium from cultured fetal human retinal pigment epithelium (RPE) cells (Tombran-Tink et al., 1991). PEDF has been shown to have neurotrophic activity in the retina in vivo (Cayouette et al., 1999). PEDF is also a neurotrophic and neuroprotective factor in other systems, including cultured cerebellar granule cells, primary hippocampal neurons, spinal cord motor neurons and amphibian photoreceptors cultured in the absence of RPE cells (Karakousis, et al., 2001). The binding of PEDF to retinoblastoma and cerebellar granule cells may be receptor-mediated. Recently, PEDF was shown to be a potent inhibitor of angiogenesis in endothelial cell cultures and in rat cornea and retina in vivo (Dawson et al., 2001; Stellmach et al., 2001).
TRUSTED_SUSTAINABILITY

Specifications

For Use With (Application) Cell Culture
Quantity 10 μg
Source Stable BHK (baby hamster kidney) cell transfectants
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