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MilliporeSigma™ Complement C1, Human, Protein

Catalog No. 204873200UG Shop All MilliporeSigma Products
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20-487-3200UG 200 μg
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Catalog No. 20-487-3200UG Supplier MilliporeSigma™ Supplier No. 204873200UG
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Description

Native, human C1 complement component. C1 is the first component of the classical complement pathway. It is a calcium-dependent complex of C1q, C1r, and C1s subcomponents which are present in the C1 complex at molar ratios of 1:2:2, respectively. Binding of C1 to classical pathway activators results in the conversion of the proenzyme C1s subcomponent to an active C1s enzyme. C1s enzyme cleaves both C4 and C2 resulting in formation of the C3 cleaving enzyme, C4b, C2a, of the classical complement pathway. C1 concentration is based on functional activity measurements relative to a normal serum standard pool.
TRUSTED_SUSTAINABILITY

Specifications

Concentration Concentration on Label
Formulation In 300mM NaCl, 50mM sodium acetate, 50mM EACA, 25μM NPGB, 10mM benzamidine, 10mM EDTA, 40% glycerol, pH 5.5.
Quantity 200 μg
Immunogen Complement C1
Storage Requirements Following initial thaw, aliquot and freeze (−70°C).
Regulatory Status RUO
Species Human
Recombinant Native
Form Liquid
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