MilliporeSigma™ Complement C1q, Human, Protein

Description

Native, human C1q complement component. Glycoprotein composed of 18 polypeptide chains consisting of three nonidentical subunits, A, B, and C, of M.W. 29kDa, 26kDa, and 19kDa, respectively. Present in normal human serum at 70μg/mL. Found in circulating blood plasma complexed with two C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of C1q to immune complexes containing IgG or IgM or to a variety of other activating substances, including C-reactive protein, retroviruses, and mitochondria. Subsequent to C1q binding, C1r and C1s are converted to proteolytic enzymes that are responsible for continuation of activation via the classical pathway.

Specifications

• Concentration: Concentration on Label
• Formulation: In 300mM NaCl, 10mM HEPES, 40% glycerol, pH 7.2.
• Purification Method: SDS-PAGE
• Quantity: 1 mg
• Immunogen: Complement C1q
• Storage Requirements: Following initial thaw, aliquot and freeze (−70°C).
• Regulatory Status: RUO
• Species: Human
• Recombinant: Native
• Form: Liquid
• Purity or Quality Grade: ≥90%