MilliporeSigma™ Complement C1r, Human, Activated, Two-Chain Form, Protein

Catalog No.	Quantity
20-487-8250UG	250 μg

Catalog No. 20-487-8250UG Supplier MilliporeSigma™ Supplier No. 204878250UG

Description

Native, human, activated, C1r complement component. Generally the non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34μg/mL. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35kDa peptide contains C1r enzymatic active site. Activated C1r continues activation via classical pathway by cleaving, and thus activating C1s.

Specifications

• Concentration: Concentration on Label
• Formulation: In 140mM NaCl, 10mM imidazole, 2mM EDTA, pH 7.4.
• Purification Method: SDS-PAGE
• Quantity: 250 μg
• Immunogen: Complement C1r
• Storage Requirements: Following initial thaw, aliquot and freeze (−70°C).
• Regulatory Status: RUO
• Structural Form: Two-Chain Form
• Species: Human
• Recombinant: Native
• Form: Liquid
• Purity or Quality Grade: ≥90%